Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Andrés Aguilera Antonio Marín Hélène Gaillard Cristina Tous Belén Gómez-González
PROVIDER: E-GEOD-24802 | ArrayExpress | 2012-06-26
SECONDARY ACCESSION(S): GSE24802PRJNA132295
REPOSITORIES: GEO, ArrayExpress
The EMBO journal 20110624 15
THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and prevents transcription-associated recombination. Whether or not it has a ubiquitous role in the genome is unknown. Chromatin immunoprecipitation (ChIP)-chip studies reveal that the Hpr1 component of THO and the Sub2 RNA-dependent ATPase have genome-wide distributions at active ORFs in yeast. In contrast to RNA polymerase II, evenly distributed from promoter to termination regions, THO and Sub2 are absent at promoters a ...[more]