Transcriptomics

Dataset Information

3

Expression data from healthy postmenopausal women on 4 different types of hormone therapy, the RET study


ABSTRACT: Postmenopausal hormone therapy (HT) is associated with many diseases and conditions, but the underlying molecular mechanisms involved are incompletely understood. The aim of the current study was to investigate the effect of 4 types of HT on gene transcription. 24 women (6 women in 4 treatment groups) received 2 mg 17β-estradiol combined with 1 mg noresthisterone acetate (NETA), 1 mg 17β-estradiol combined with 0.5 mg NETA, tibolone, or raloxifene hydrochloride. RNA was isolated from whole blood before treatment (baseline) and after 6 weeks on treatment. The changes in mRNA from baseline to 6 weeks were assessed with a microarray chip. 4 treatment groups with 6 women in each group were blood sampled before treatment (baseline) and after 6 weeks on treatment, that is a total of 48 samples. The gene expression data at 6 weeks were compared to the expression data at baseline for each treatment.

ORGANISM(S): Homo sapiens  

SUBMITTER: Reidun Øvestebø   Anders Erik Astrup Dahm  Ole K Olstad  Marie-Christine Mowinchel  Peter Kierulf  Anette L Eilertsen  Per M Sandset  Anders E Dahm  Jelle J Goeman  Grethe Skretting 

PROVIDER: E-GEOD-24859 | ArrayExpress | 2012-01-17

SECONDARY ACCESSION(S): GSE24859PRJNA132113

REPOSITORIES: GEO, ArrayExpress

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Publications

A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women.

Dahm Anders E A AE   Eilertsen Anette L AL   Goeman Jelle J   Olstad Ole Kristoffer OK   Ovstebø Reidun R   Kierulf Peter P   Mowinckel Marie-Christine MC   Skretting Grethe G   Sandset Per Morten PM  

Thrombosis research 20120102 1


BACKGROUND: Postmenopausal hormone therapy is associated with many diseases and conditions, e.g., cardiovascular diseases and asthma, but the underlying molecular mechanisms are incompletely understood. The aim of the current study was to investigate the effect of four different postmenopausal hormone therapy regimens on gene transcription. MATERIALS AND METHODS: Twenty-four healthy postmenopausal women (six women in four groups) were randomly allocated to conventional-dose 17β-estradiol/norethi  ...[more]

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