Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Shenghui Duan Katie A Matatall Michael D Onken Elisha D.O. Roberson M L Council Elisha D Roberson Lori A Worley J W Harbour Anne M Bowcock Li Cao Cynthia Helms
PROVIDER: E-GEOD-24896 | ArrayExpress | 2011-01-06
SECONDARY ACCESSION(S): GSE24896PRJNA132077
REPOSITORIES: GEO, ArrayExpress
Science (New York, N.Y.) 20101104 6009
Metastasis is a defining feature of malignant tumors and is the most common cause of cancer-related death, yet the genetics of metastasis are poorly understood. We used exome capture coupled with massively parallel sequencing to search for metastasis-related mutations in highly metastatic uveal melanomas of the eye. Inactivating somatic mutations were identified in the gene encoding BRCA1-associated protein 1 (BAP1) on chromosome 3p21.1 in 26 of 31 (84%) metastasizing tumors, including 15 mutati ...[more]