Dataset Information


Global expression analysis of BAP1 knockdown in transfected 92.1 cells

ABSTRACT: Analysis of the effect that reduced BAP1 levels have on global gene expression.The hypothesis tested was that reduction in BAP1 levels would produce changes in gene expression similar to changes observed in class 2 uveal melanomas. Data provided insight into genes that are disrupted with reduced BAP1 levels. Total RNA was isolated from 92.1 cells transfected with either control or BAP1 knockdown constructs for global expression analysis.

ORGANISM(S): Homo sapiens  

SUBMITTER: Shenghui Duan   Katie A Matatall  Michael D Onken  Elisha D.O. Roberson  M L Council  Elisha D Roberson  Lori A Worley  J W Harbour  Anne M Bowcock  Li Cao  Cynthia Helms 

PROVIDER: E-GEOD-24896 | ArrayExpress | 2011-01-06



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Metastasis is a defining feature of malignant tumors and is the most common cause of cancer-related death, yet the genetics of metastasis are poorly understood. We used exome capture coupled with massively parallel sequencing to search for metastasis-related mutations in highly metastatic uveal melanomas of the eye. Inactivating somatic mutations were identified in the gene encoding BRCA1-associated protein 1 (BAP1) on chromosome 3p21.1 in 26 of 31 (84%) metastasizing tumors, including 15 mutati  ...[more]

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