Transcriptomics

Dataset Information

93

Identification of stromally expressed molecules in the prostate by Tag profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate


ABSTRACT: The stromal microenvironment plays key roles in prostate development and cancer. Cancer associated fibroblasts (CAFs) and other stromal cells stimulate tumourigenesis via several mechanisms including the expression of pro-tumourigenic factors. Mesenchyme (embryonic stroma) controls prostate organogenesis, and in some circumstances can re-differentiate prostate tumours. Epithelia are regulated by powerful paracrine signalling from the stroma in both development and disease, and identification of these stromal signals is important. We have applied next-generation Tag profiling to fetal human prostate, normal human prostate fibroblasts (NPFs) and CAFs to identify molecules expressed in prostatic stroma Each sample was used for Tag library construction, by Solexa Inc

ORGANISM(S): Homo sapiens  

SUBMITTER: Axel Thomson  Axel A Thomson    

PROVIDER: E-GEOD-25018 | ArrayExpress| 2013-04-03

SECONDARY ACCESSION(S): SRP004042GSE25018PRJNA134387

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate.

Orr B B   Riddick A C P AC   Stewart G D GD   Anderson R A RA   Franco O E OE   Hayward S W SW   Thomson A A AA  

Oncogene 20110801 9


The stromal microenvironment has key roles in prostate development and cancer, and cancer-associated fibroblasts (CAFs) stimulate tumourigenesis via several mechanisms including the expression of pro-tumourigenic factors. Mesenchyme (embryonic stroma) controls prostate organogenesis, and in some circumstances can re-differentiate prostate tumours. We have applied next-generation Tag profiling to fetal human prostate, normal human prostate fibroblasts (NPFs) and CAFs to identify molecules express  ...[more]

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