Dataset Information


Fetal Rat Testis mRNA Expression after 50 mg/kg Dibutyl Phthalate Exposure

ABSTRACT: High dose level dibutyl phthalate (DBP) exposure of fetal rat testes in vivo inhibits testosterone production (i.e. endocrine disruption). Here, fetal testis mRNA levels were profiled following exposure to a DBP dose level that did not significantly reduce testosterone levels. The goal was to identify the constellation of gene expression changes that do not correlate with endocrine disruption. Fischer 344 rats were exposed via oral gavage of the dam to vehicle (corn oil) or 50 mg/kg (body weight) DBP daily from gestational day (GD) 12 to 20. The day after mating was defined as gestational day 0. Six hours after the final exposure on GD20, fetal testes were dissected and mRNA levels quantified using Affymetrix Rat Expression 230 2.0 microarrays.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Kamin J Johnson   Qing Xia 

PROVIDER: E-GEOD-25196 | ArrayExpress | 2011-04-25



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Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways.

Johnson Kamin J KJ   McDowell Erin N EN   Viereck Megan P MP   Xia Jessie Q JQ  

Toxicological sciences : an official journal of the Society of Toxicology 20110125 2

Fetal rat phthalate exposure produces a spectrum of male reproductive tract malformations downstream of reduced Leydig cell testosterone production, but the molecular mechanism of phthalate perturbation of Leydig cell function is not well understood. By bioinformatically examining fetal testis expression microarray data sets from susceptible (rat) and resistant (mouse) species after dibutyl phthalate (DBP) exposure, we identified decreased expression of several metabolic pathways in both species  ...[more]

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