Transcriptomics

Dataset Information

2

Identification of target genes of miR-193b


ABSTRACT: Searching of target genes of miR-193b by transcriptome assay using 44K Whole Human Genome Microarray system (Agilent Technologies, Palo Alto, CA) resulted in finding of several candidate genes. To search of targets genes of miR-193b, we performed transcriptome analysis to compare expression profiles between human pancreatic cancer cells, MIA PaCa-2, transfected with precursor of miR-193b and those transfected with a negative control precursor.

ORGANISM(S): Homo sapiens  

SUBMITTER: Yushi Ikeda   Etsuko Tanji  Sumio Kawata  Toru Furukawa  Naohiko Makino 

PROVIDER: E-GEOD-25215 | ArrayExpress | 2012-03-14

SECONDARY ACCESSION(S): GSE25215PRJNA134335

REPOSITORIES: GEO, ArrayExpress

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Publications

MicroRNAs associated with mitogen-activated protein kinase in human pancreatic cancer.

Ikeda Yushi Y   Tanji Etsuko E   Makino Naohiko N   Kawata Sumio S   Furukawa Toru T  

Molecular cancer research : MCR 20111221 2


Aberrant expression of microRNAs (miRNA) is associated with phenotypes of various cancers, including pancreatic cancer. However, the mechanism of the aberrant expression is largely unknown. Activation of the mitogen-activated protein kinase (MAPK) signaling pathway plays a crucial role in gene expression related to the malignant phenotype of pancreatic cancer. Hence, we studied the role of MAPK in the aberrant expression of miRNAs in pancreatic cancer cells. The alterations in expression of 183  ...[more]

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