Transcriptomics

Dataset Information

9

Genome-Wide Expression Profiling of human tumor-infiltrating microglia/macrophages stimulated by Toll-like receptor 3 agonist poly (I:C)


ABSTRACT: Microglia isolated from glioma patients gain anti-tumor activities upon poly (I:C) stimulation. Expression profiles of human tumor-infiltrating microglia/macrophages before (untreated) and after treatment with poly (I:C) for 48h (induced). Tumor-infiltrating microglia/macrophages were isolated from freshly excised brain tumors

ORGANISM(S): Homo sapiens  

SUBMITTER: Aurelie Ernst   Christine Falk  Rodrigo Mora  Bernhard Radelwimmer  Christel Herold-Mende  Tim Kees  Georg Gdynia  Anne Regnier-Vigouroux  Grischa Toedt  Jennifer Lohr 

PROVIDER: E-GEOD-25289 | ArrayExpress | 2011-12-31

SECONDARY ACCESSION(S): GSE25289PRJNA134889

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation.

Kees Tim T   Lohr Jennifer J   Noack Johannes J   Mora Rodrigo R   Gdynia Georg G   Tödt Grischa G   Ernst Aurélie A   Radlwimmer Bernhard B   Falk Christine S CS   Herold-Mende Christel C   Régnier-Vigouroux Anne A  

Neuro-oncology 20111020 1


The role of microglia, the brain-resident macrophages, in glioma biology is still a matter of debate. Clinical observations and in vitro studies in the mouse model indicate that microglia and macrophages that infiltrate the brain tumor tissue in high numbers play a tumor-supportive role. Here, we provide evidence that human microglia isolated from brain tumors indeed support tumor cell growth, migration, and invasion. However, after stimulation with the Toll-like receptor 3 agonist poly (I:C), m  ...[more]

Similar Datasets

2011-12-31 | GSE25289 | GEO
2013-11-13 | E-GEOD-46688 | ArrayExpress
2018-07-17 | GSE71365 | GEO
2013-11-13 | E-GEOD-46686 | ArrayExpress
| PRJNA134889 | ENA
2015-07-13 | E-GEOD-46686 | ExpressionAtlas
2009-05-30 | GSE16119 | GEO
2014-10-20 | E-GEOD-59725 | ArrayExpress
| GSE59725 | GEO
2020-10-12 | E-MTAB-8059 | ArrayExpress