Dataset Information


Genome-Wide Expression Profiling of human tumor-infiltrating microglia/macrophages stimulated by Toll-like receptor 3 agonist poly (I:C)

ABSTRACT: Microglia isolated from glioma patients gain anti-tumor activities upon poly (I:C) stimulation. Expression profiles of human tumor-infiltrating microglia/macrophages before (untreated) and after treatment with poly (I:C) for 48h (induced). Tumor-infiltrating microglia/macrophages were isolated from freshly excised brain tumors

ORGANISM(S): Homo sapiens  

SUBMITTER: Aurelie Ernst   Christine Falk  Rodrigo Mora  Bernhard Radelwimmer  Christel Herold-Mende  Tim Kees  Georg Gdynia  Anne Regnier-Vigouroux  Grischa Toedt  Jennifer Lohr 

PROVIDER: E-GEOD-25289 | ArrayExpress | 2011-12-31



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Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation.

Kees Tim T   Lohr Jennifer J   Noack Johannes J   Mora Rodrigo R   Gdynia Georg G   Tödt Grischa G   Ernst Aurélie A   Radlwimmer Bernhard B   Falk Christine S CS   Herold-Mende Christel C   Régnier-Vigouroux Anne A  

Neuro-oncology 20111020 1

The role of microglia, the brain-resident macrophages, in glioma biology is still a matter of debate. Clinical observations and in vitro studies in the mouse model indicate that microglia and macrophages that infiltrate the brain tumor tissue in high numbers play a tumor-supportive role. Here, we provide evidence that human microglia isolated from brain tumors indeed support tumor cell growth, migration, and invasion. However, after stimulation with the Toll-like receptor 3 agonist poly (I:C), m  ...[more]

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