Dataset Information


Genome-wide comparison of H3K27me3 difference between ref6-1 and wild type Col

ABSTRACT: We demonstrate that REF6/JMJ12 (RELATIVE OF EARLY FLOWERING 6/Jumonji domain-containing protein 12) could demethylate H3K27me3. Loss of REF6/JMJ12 leads to ectopic and increased H3K27me3 of a large spectrum of genes involved in development and responses to stimuli. Examination of differences in H3K27me3 between ref6-1 and wild type Col.

ORGANISM(S): Arabidopsis thaliana  

SUBMITTER: Xia Cui   Falong Lu  Xiaofeng Cao 

PROVIDER: E-GEOD-25446 | ArrayExpress | 2011-05-25



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Arabidopsis REF6 is a histone H3 lysine 27 demethylase.

Lu Falong F   Cui Xia X   Zhang Shuaibin S   Jenuwein Thomas T   Cao Xiaofeng X  

Nature genetics 20110605 7

Polycomb group (PcG)-mediated histone H3 lysine 27 trimethylation (H3K27me3) has a key role in gene repression and developmental regulation. There is evidence that H3K27me3 is actively removed in plants, but it is not known how this occurs. Here we show that RELATIVE OF EARLY FLOWERING 6 (REF6), also known as Jumonji domain-containing protein 12 (JMJ12), specifically demethylates H3K27me3 and H3K27me2, whereas its metazoan counterparts, the KDM4 proteins, are H3K9 and H3K36 demethylases. Plants  ...[more]

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