Dataset Information


Promoter methylation data: OHT/ICI-sensitive vs. -resistant cell lines

ABSTRACT: MCF7 breast cancer cell lines: drug-resistant (OHT and ICI) cell lines vs. drug-sensitive (wild type) cell lines. Assessment of association between gene expression and methylation. Two comparisons: OHT-resistant vs. wild type, and ICI-resistant vs. wild type. OHT: 4-hydroxytamoxifen ICI: fulvestrant ((ICI 182780) This submission represents the methylation component of the study.

ORGANISM(S): Homo sapiens  

SUBMITTER: Kenneth P Nephew   Jaesik Jeong 

PROVIDER: E-GEOD-25519 | ArrayExpress | 2011-10-04



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An empirical Bayes model for gene expression and methylation profiles in antiestrogen resistant breast cancer.

Jeong Jaesik J   Li Lang L   Liu Yunlong Y   Nephew Kenneth P KP   Huang Tim Hui-Ming TH   Shen Changyu C  

BMC medical genomics 20101125

The nuclear transcription factor estrogen receptor alpha (ER-alpha) is the target of several antiestrogen therapeutic agents for breast cancer. However, many ER-alpha positive patients do not respond to these treatments from the beginning, or stop responding after being treated for a period of time. Because of the association of gene transcription alteration and drug resistance and the emerging evidence on the role of DNA methylation on transcription regulation, understanding of these relationsh  ...[more]

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