Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Vittorio Sartorelli Kambiz Mousavi Hossein Zare A H Wang
PROVIDER: E-GEOD-25549 | ArrayExpress | 2011-11-23
SECONDARY ACCESSION(S): SRP004638SRP004636GSE25549PRJNA134029
REPOSITORIES: GEO, ArrayExpress, ENA
Molecular cell 20111222 2
Polycomb group (PcG) proteins initiate the formation of repressed chromatin domains and regulate developmental gene expression. A mammalian PcG protein, enhancer of zeste homolog 2 (Ezh2), triggers transcriptional repression by catalyzing the addition of methyl groups onto lysine 27 of histone H3 (H3K27me2/3). This action facilitates the binding of other PcG proteins to chromatin for purposes of transcriptional silencing. Interestingly, there exists a paralog of Ezh2, termed Ezh1, whose primary ...[more]