Transcriptomics

Dataset Information

9

Transcription profiling by array of human mucosa-associated lymphoid tissue lymphoma with chromosomal translocation (11;18)


ABSTRACT: Comparison of t(11;18)-positive MALT lymphoma to t(11;18)-negative MALT lymphoma, with a special focus on the NF-KB pathway and it's targets 8 t(11;18)-negative and 6 t(11;18)-positive cases of MALT lymphoma, as well as six spleen control samples (1 mix of spleens and 5 singular spleen samples)

ORGANISM(S): Homo sapiens  

SUBMITTER: Mathijs Baens   Joke Allemeersch  Peter Van Loo  Xavier Sagaert 

PROVIDER: E-GEOD-25550 | ArrayExpress | 2010-11-25

SECONDARY ACCESSION(S): GSE25550PRJNA134031

REPOSITORIES: GEO, ArrayExpress

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Publications


Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma induces proteolytic cleavage of NF-κB-inducing kinase (NIK) at arginine 325. NIK cleavage requires the concerted actions of both fusion partners and generates a C-termina  ...[more]

Publication: 1/2

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