Transcriptomics,Multiomics

Dataset Information

5

Expression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia – unexpected expression pattern of the RHO GTPase activator ARHGAP20

ABSTRACT: In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is not known. ARHGAP20 encodes an evolutionarily conserved protein. In the zebra fish (Danio rerio) genome the syntenic regions of human chromosomal bands 13q14 and 11q22-23 are juxtaposed. The similar expression profiles of ARHGAP20 in 13q14 and 11q22-23 deleted CLL cases suggest a molecular connection and an intriguing mechanism of regulation. Analysis of 154 samples of peripheral blood mononuclear cells (109 HGU-133plus2; 45 HGU-133A; 45 HGU-133B) from adult patients with chronic lymphocytic leukemia (CLL).

OTHER RELATED OMICS DATASETS IN: PRJNA133883

ORGANISM(S): Homo sapiens  

SUBMITTER: Annika Dufour   Purvi Kakadia  Vindi Jurinovic  Medhanie Mulaw  Tobias Herold  Stefan Bohlander  Karsten Spiekermann  Stephanie Schneider  Ulrich Mansmann  Christian Buske  Wolfgang Hiddemann  Jan Braess  Michaela Feuring-Buske  Till Seiler 

PROVIDER: E-GEOD-25571 | ArrayExpress | 2011-10-13

SECONDARY ACCESSION(S): GSE25571PRJNA133883

REPOSITORIES: GEO, ArrayExpress

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Publications

Expression analysis of genes located in the minimally deleted regions of 13q14 and 11q22-23 in chronic lymphocytic leukemia-unexpected expression pattern of the RHO GTPase activator ARHGAP20.

Herold Tobias T   Jurinovic Vindi V   Mulaw Medhanie M   Seiler Till T   Dufour Annika A   Schneider Stephanie S   Kakadia Purvi M PM   Feuring-Buske Michaela M   Braess Jan J   Spiekermann Karsten K   Mansmann Ulrich U   Hiddemann Wolfgang W   Buske Christian C   Bohlander Stefan K SK  

Genes, chromosomes & cancer 20110415 7

In chronic lymphocytic leukemia (CLL), 13q14 and 11q22-23 deletions are found in 2/3 of the cases. 11q22-23 deletions are associated with poor survival, whereas 13q14 deletions as single abnormality are often found in indolent disease forms. The molecular basis for this difference in prognosis is not known. We examined the 13q14 and 11q22-23 minimally deleted regions (MDRs) for differentially expressed genes by analyzing 154 microarray CLL gene expression data sets. We were able to generate a de  ...[more]

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