Transcriptomics

Dataset Information

3

The genes regulated by SOX11 in mantle cell lymphoma


ABSTRACT: The genes regulated by SOX11 in MCL was investigated in MCL cell line Granta 519 by siRNA knock down system. Cells were transfected using the LONZA electroporation system. Results represent cells harvested after 20 hours. Details of the experiment is published in PMID 21124928. Gene expression profiles (Human Gene 1.0 ST) of mantle cell lymphoma (MCL) cell line Granta 519 treated with SOX11 siRNA. Data analyses were performed using the Affymetrix Expression Console (v. 1.1)

ORGANISM(S): Homo sapiens  

SUBMITTER: Birgitta Sander   Xiao Wang  David Brodin 

PROVIDER: E-GEOD-25621 | ArrayExpress | 2010-11-29

SECONDARY ACCESSION(S): GSE25621PRJNA133969

REPOSITORIES: GEO, ArrayExpress

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Publications

Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma.

Wang Xiao X   Björklund Stefan S   Wasik Agata M AM   Grandien Alf A   Andersson Patrik P   Kimby Eva E   Dahlman-Wright Karin K   Zhao Chunyan C   Christensson Birger B   Sander Birgitta B  

PloS one 20101122 11


The SRY (sex determining region Y)-box 11 (SOX11) gene, located on chromosome 2p25, encodes for a transcription factor that is involved in tissue remodeling during embryogenesis and is crucial for neurogenesis. The role for SOX11 in hematopoiesis has not yet been defined. Two genes under direct control of SOX11 are the class- III β-tubulin gene (TUBB3) in neural cells and the transcription factor TEA domain family member 2 (TEAD2) in neural and mesenchymal progenitor cells. Normal, mature lympho  ...[more]

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