Transcriptomics

Dataset Information

8

Transcription profiling of rat muscle samples from reinnervated subjects


ABSTRACT: Three male 8-week-old Wistar rats were used. The peroneal nerve of the animals was transected and sutured to the biceps femoris muscle. Four weeks later, the proximal stump was sutured to the distal stump. The animals survived for 8 weeks. All experiments were performed under Ketanest (ketamine hydrochloride, Essex Pharma GmbH, Munich, Germany; 100 mg/kg) and Rompun (xylazine hydrochloride, Bayer, Leverkusen, Germany; 10 mg/kg) anesthesia. Both substances were injected intraperitoneally. RNA was extracted from the ipsilateral and contralateral tibialis anterior muscles of each animal. The gene array analysis compared the ipsilateral muscle with the contralateral muscle of each animal.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Antje Bornemann  

PROVIDER: E-GEOD-2566 | ArrayExpress | 2007-11-03

SECONDARY ACCESSION(S): GDS2243GSE2566PRJNA91971

REPOSITORIES: GEO, ArrayExpress

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Publications

Reinnervation-induced alterations in rat skeletal muscle.

Zhou Z   Cornelius CP   Eichner M   Bornemann A  

Neurobiology of disease 20060731 3


Denervation-induced myofiber atrophy can be reversed by reinnervation. Growing reinnervated myofibers upregulate numerous molecules, many of which determine the muscle fiber type. In the present study we aimed at identifying factors that might contribute specifically to myofiber growth after reinnervation. The common peroneal nerve of 15 male Wistar rats was cut and resutured without delay (9 animals) or with a delay of 4 weeks (6 animals). We studied the transcriptional repertoire of intact rei  ...[more]

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