Transcriptomics

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Contrasting patterns of expression divergence in early and late stages of population divergence in mice


ABSTRACT: We compared gene expression differences in the polytypic species complex Mus musculus (Mus musculus musculus, Mus musculus domesticus, Mus musculus castaneus and Mus musculus ssp) with that of Mus spretus via oligonucleotide microarrays representing more than 20,000 genes. Analysis of the results by two way ANOVA statistics suggests that the most genes with significant differences in expression levels among the subspecies are found in liver and kidney and the least in testis. This picture is different when one compares with Mus spretus, where the largest number of differences is found in testis. The design we employed is a reference design. All tissues were hybridized against a pool of that same tissue from 9 C57BL6 mice. All mice were roughly 12 weeks of age. To control for biological variation, we have used several individual males from each sub-species. RNA was isolated from three different organs, namely brain, liver/kidney and testis.

ORGANISM(S): Musculus  

SUBMITTER: Christian Voolstra   Bettina Harr   Patrick Farbrother  Ludwig Eichinger  Chris Voolstra  Diethard Tautz 

PROVIDER: E-GEOD-2597 | ArrayExpress | 2010-06-30

SECONDARY ACCESSION(S): GSE2597PRJNA92009

REPOSITORIES: GEO, ArrayExpress

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Publications

Contrasting evolution of expression differences in the testis between species and subspecies of the house mouse.

Voolstra Christian C   Tautz Diethard D   Farbrother Patrick P   Eichinger Ludwig L   Harr Bettina B  

Genome research 20061012 1


Regulatory changes in genes involved in reproduction are thought to be prime targets for divergence during speciation, since they are expected to play an important role in sexual selection and sexual conflict. We used microarray analysis of RNA from different wild populations of house mouse subspecies (including Mus m. musculus, Mus m. domesticus, and Mus m. castaneus) and from the sister species Mus spretus to test this assumption. A comparison of expression divergence in brain, liver/kidney, a  ...[more]

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