Transcriptomics

Dataset Information

2

Transcription profiling by array of Drosophila dLmo loss-of-function and gain-of-function mutants


ABSTRACT: The Drosophila gene dLmo encodes a transcriptional regulator involved in wing development and behavioral responses to cocaine and ethanol. We were interested in discovering novel transcriptional targets of dLmo in the nervous system by examining gene expression changes in the heads of wild-type flies and flies carrying dLmo loss-of-function (EP1306) and gain-of-function mutants (BxJ). RNA was isolated from 3 pooled groups of 200 fly heads from each genotype (w;iso control, EP1306, and BxJ) and hybridized to triplicate Affymetrix Drosophila 2.0 oligonucleotide microarray chips at the Partners HealthCare Center for Personalized Genetic Medicine microarray facility (Harvard University).

REANALYSED by: E-GEOD-25988

ORGANISM(S): Drosophila melanogaster  

SUBMITTER: Amy W Lasek   Amy Lasek  Ulrike Heberlein  Monica S Moore 

PROVIDER: E-GEOD-25988 | ArrayExpress | 2011-02-01

SECONDARY ACCESSION(S): GSE25988PRJNA135415

REPOSITORIES: GEO, ArrayExpress

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Publications


Anaplastic lymphoma kinase (Alk) is a gene expressed in the nervous system that encodes a receptor tyrosine kinase commonly known for its oncogenic function in various human cancers. We have determined that Alk is associated with altered behavioral responses to ethanol in the fruit fly Drosophila melanogaster, in mice, and in humans. Mutant flies containing transposon insertions in dAlk demonstrate increased resistance to the sedating effect of ethanol. Database analyses revealed that Alk expres  ...[more]

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