Transcriptomics

Dataset Information

11

Transcription profiling of rat spinal cord contusion 35 days after injury


ABSTRACT: Excerpt from a larger study which characterized the transcriptional effects of a spinal cord contusion injury in rats. This is the data from the almost chronic contusion state (35 days) at the injury site (Thoracic 8) - where we saw significant changes in several areas, including cholesterol metabolism genes. Other spinal cord areas (rostral, caudal) and time-points (3 hours, 24 hours, 7 days and 35 days) were analyzed as well and are discussed in our paper and at www.crpf.org/microarray.

ORGANISM(S): Rattus norvegicus  

DISEASE(S): Uninjured,Contused

SUBMITTER: James Bradley Aimone  

PROVIDER: E-GEOD-2599 | ArrayExpress | 2007-10-08

SECONDARY ACCESSION(S): GDS1238GSE2599PRJNA92013

REPOSITORIES: GEO, ArrayExpress

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Publications

Spatial and temporal gene expression profiling of the contused rat spinal cord.

Aimone James B JB   Leasure J Leigh JL   Perreau Victoria M VM   Thallmair Michaela M  

Experimental neurology 20041001 2


Microarray technology was used to examine gene expression changes following contusive injury of the adult rat spinal cord. To obtain a global understanding of the changes triggered by the injury, differential gene expression was examined spatially, using tissue samples from the epicenter of injury as well as 1 cm rostral and 1 cm caudal to the epicenter, and temporally, at 3 h, 24 h, 7 days, and 35 days post-injury. To filter out gene expression changes that were due to the laminectomy, samples  ...[more]

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