Transcriptomics

Dataset Information

3

Genomic profiles vary with race and subtype in young African American and European American breast cancer (SNP)


ABSTRACT: In the United States, African-American (AA) women are more likely to develop early-onset breast cancer and have historically poorer outcomes due to this disease compared to European-American (EA) women. Here, we analyzed genomic profiles of breast tumors from young women (<50 years old), matched by tumor subtype, histological grade, and ethnicity (African-American, AA, compared to European-American, EA). DNA copy number alterations (CNAs) were analyzed on the Affymetrix Human SNP Array v 6.0 platform. The study provides insight into the genetic component of ethnicity-related breast cancer health disparities. DNA copy number alterations (CNAs) and genotypes were analyzed using the Affymetrix SNP 6.0 platform. Breast tumor samples from young women (< 50 years old) were matched as follows: a matched pair consists of one AA and one EA sample, matched for tumor grade and tumor subtype (based on immunohistochemical analysis of ER, PR, and HER2 status). DNA from forty-four samples (22 AA, 22 EA) was analyzed on the Affymetrix SNP 6.0 array according to manufacturer’s directions.

ORGANISM(S): Homo sapiens  

SUBMITTER: Tyesha L Farmer   Theresa V Strong  Theresa V Strong 

PROVIDER: E-GEOD-26232 | ArrayExpress | 2013-01-29

SECONDARY ACCESSION(S): GSE26232PRJNA142335

REPOSITORIES: GEO, ArrayExpress

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