Dataset Information


ChIP-seq for CTCF and Rad21 in Rag1−/− pro-B cells

ABSTRACT: Genome-wide ChIP data of CTCF and Rad21 binding in Rag1−/− pro-B cells CTCF and Rad21 binding in Rag1−/− pro-B

ORGANISM(S): Mus musculus  

SUBMITTER: A Torkamani   S C Degner  Ali Torkamani  Ann J Feeney 

PROVIDER: E-GEOD-26257 | ArrayExpress | 2011-06-07



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CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells.

Degner Stephanie C SC   Verma-Gaur Jiyoti J   Wong Timothy P TP   Bossen Claudia C   Iverson G Michael GM   Torkamani Ali A   Vettermann Christian C   Lin Yin C YC   Ju Zhongliang Z   Schulz Danae D   Murre Caroline S CS   Birshtein Barbara K BK   Schork Nicholas J NJ   Schlissel Mark S MS   Riblet Roy R   Murre Cornelis C   Feeney Ann J AJ  

Proceedings of the National Academy of Sciences of the United States of America 20110523 23

Compaction and looping of the ~2.5-Mb Igh locus during V(D)J rearrangement is essential to allow all V(H) genes to be brought in proximity with D(H)-J(H) segments to create a diverse antibody repertoire, but the proteins directly responsible for this are unknown. Because CCCTC-binding factor (CTCF) has been demonstrated to be involved in long-range chromosomal interactions, we hypothesized that CTCF may promote the contraction of the Igh locus. ChIP sequencing was performed on pro-B cells, revea  ...[more]

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