Transcriptomics

Dataset Information

17

Transcription profiling of human umbilical cord blood and adult bone marrow CD34+CD33-CD38-Rho(lo)c-kit+ cells to identify candidate regulators of HSC self-renewal versus differentiation fate decisions


ABSTRACT: The global gene expression profiles of human umbilical cord blood and adult bone marrow CD34+CD33-CD38-Rho(lo)c-kit+ cells, enriched for hematopoietic stem/progenitor cells (HSC) with CD34+CD33-CD38-Rho(hi) cells, enriched in committed hematopoietic progenitor cells (HPC), were compared to identify candidate regulators of HSC self-renewal versus differentiation fate decisions.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

TISSUE(S): Umbilical Cord, Bone Marrow

DISEASE(S): Mas

SUBMITTER: Craig E. Eckfeldt  

PROVIDER: E-GEOD-2666 | ArrayExpress | 2007-10-30

SECONDARY ACCESSION(S): GDS1230GDS1231GSE2666PRJNA92097

REPOSITORIES: GEO, ArrayExpress

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Publications

Functional analysis of human hematopoietic stem cell gene expression using zebrafish.

Eckfeldt Craig E CE   Mendenhall Eric M EM   Flynn Catherine M CM   Wang Tzu-Fei TF   Pickart Michael A MA   Grindle Suzanne M SM   Ekker Stephen C SC   Verfaillie Catherine M CM  

PLoS biology 20050705 8


Although several reports have characterized the hematopoietic stem cell (HSC) transcriptome, the roles of HSC-specific genes in hematopoiesis remain elusive. To identify candidate regulators of HSC fate decisions, we compared the transcriptome of human umbilical cord blood and bone marrow (CD34+)(CD33-)(CD38-)Rho(lo)(c-kit+) cells, enriched for hematopoietic stem/progenitor cells with (CD34+)(CD33-)(CD38-)Rho(hi) cells, enriched in committed progenitors. We identified 277 differentially expresse  ...[more]

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