Transcriptomics

Dataset Information

65

MicroRNA expression profiling of quiescent and activated muscle stem cells


ABSTRACT: MicroRNA expression profiling during muscle stem cell activation. Quiescent muscle stem cells from uninjured muscles and activated muscle stem cells from injured muscles at indicated time points were isolated by FACS. MicroRNA expression profiling during muscle stem cell activation using real-time PCR based miRNA arrays. Muscle stem cells were harvested at indicated time points (0hr, 36hr, 60hr and 72hr) after injury. 3 technical replicates were performed. Supplementary files: Raw data (Ct) and complete processed data (dCt, ddCt, fold-change) by platform.

ORGANISM(S): Mus musculus  

SUBMITTER: Tom H Cheung   Thomas A Rando 

PROVIDER: E-GEOD-26780 | ArrayExpress | 2012-01-01

SECONDARY ACCESSION(S): GSE26780PRJNA136277

REPOSITORIES: GEO, ArrayExpress

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Publications


Among the key properties that distinguish adult mammalian stem cells from their more differentiated progeny is the ability of stem cells to remain in a quiescent state for prolonged periods of time. However, the molecular pathways for the maintenance of stem-cell quiescence remain elusive. Here we use adult mouse muscle stem cells (satellite cells) as a model system and show that the microRNA (miRNA) pathway is essential for the maintenance of the quiescent state. Satellite cells that lack a fun  ...[more]

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