Dataset Information


Structural variation of the gorilla genome

ABSTRACT: Structural variation has played an important role in the evolutionary restructuring of human and great ape genomes. We generated approximately 10-fold genomic sequence coverage from a western lowland gorilla and integrated these data into a physical and cytogenetic framework to develop a comprehensive view of structural variation. We discovered and validated over 7,665 structural changes within the gorilla lineage including sequence resolution of inversions, deletions, duplications and retrotranspositions. A comparison with human and other ape genomes shows that the gorilla genome has been subjected to the highest rate of segmental duplication. We show that both the gorilla and chimpanzee genomes have experienced independent yet parallel patterns of structural mutation that have not occurred in humans, including the formation of subtelomeric heterochromatic caps, the hyperexpansion of segmental duplications and bursts of retroviral integrations. Our analysis suggests that the chimpanzee and gorilla genomes are structurally more derived than either orangutan or human. all combinations of human, chimpanzee and gorilla are used in 2 different arrayCGH designs. First, a standard 2.1 was used to detected CNVs, and second, we used a custom designed arrayCGH to validate gorilla specific duplications and deletions

SUBMITTER: Tina Graves   Lin Chen  Mario Ventura  Tomas Marques-Bonet  Jay Shendure  Fereydoun Hormozdiari  Carl Baker  Lee Choli  Jeff Kidd  Maika Malig  Emily Turner  Saba Sajjadian  Claudia Catacchio  Evan E Eichler  Can Alkan  Richard K Wilson  Nicoletta Archidicacono 

PROVIDER: E-GEOD-27072 | ArrayExpress | 2011-05-01



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