Transcriptomics

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Gene expression profiles of mouse Blimp1 +/gfp and Blimp1 gfp/gfp regulatory T cells


ABSTRACT: Regulatory T (Treg) cells are required for peripheral tolerance. Recent evidence indicates that Treg cells can adopt specialized differentiation programs in the periphery that are controlled by transcription factors usually associated with T helper differentiation. We demonstrate that expression of the transcription factor Blimp1 defines a population of Treg cells that localize predominantly to mucosal sites and produces IL-10. Blimp1 is required for IL-10 production by these cells and for their tissue homeostasis. A list of differentially expressed genes were identified from this whole-genome expression profiling experiment. Mouse Blimp1 +/gfp and Blimp1 gfp/gfp regulatory T cells were analyzed. Three replicates each.

ORGANISM(S): Mus musculus  

SUBMITTER: Wei Shi  Stephen L Nutt   Axel Kallies   Gordon K Smyth    

PROVIDER: E-GEOD-27143 | ArrayExpress | 2011-02-09

SECONDARY ACCESSION(S): GSE27143PRJNA137577

REPOSITORIES: GEO, ArrayExpress

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