Transcriptomics

Dataset Information

4

Donor cell type influences the epigenome and differentiation potential of human induced pluripotent stem cells


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE27134: DNA methylation data from human iPS cells, ES cells, cord blood, and keratinocytes GSE27186: Expression data of human somatic cell types and induced pluripotent stem cells GSE31742: DNA methylation data from human keratinocyte-derived iPS cells (N9) and ES cells Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Kitai Kim   George Q Daley  Patrick Cahan  Andrew P Feinberg  Akiko Doi 

PROVIDER: E-GEOD-27224 | ArrayExpress | 2011-11-29

SECONDARY ACCESSION(S): GSE27224PRJNA137501

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells.

Kim Kitai K   Zhao Rui R   Doi Akiko A   Ng Kitwa K   Unternaehrer Juli J   Cahan Patrick P   Huo Hongguang H   Loh Yuin-Han YH   Aryee Martin J MJ   Lensch M William MW   Li Hu H   Collins James J JJ   Feinberg Andrew P AP   Daley George Q GQ  

Nature biotechnology 20111127 12


We compared bona fide human induced pluripotent stem cells (iPSCs) derived from umbilical cord blood (CB) cells and neonatal keratinocytes (K). As a consequence of both incomplete erasure of tissue-specific methylation and aberrant de novo methylation, CB-iPSCs and K-iPSCs were distinct in genome-wide DNA methylation profiles and differentiation potential. Extended passage of some iPSC clones in culture did not improve their epigenetic resemblance to embryonic stem cells, implying that some huma  ...[more]

Similar Datasets

2011-11-29 | E-GEOD-31742 | ArrayExpress
2010-10-20 | E-GEOD-24820 | ArrayExpress
2011-11-29 | E-GEOD-27134 | ArrayExpress
2010-07-19 | E-GEOD-22851 | ArrayExpress
2009-10-31 | E-GEOD-18227 | ArrayExpress
2010-09-14 | E-GEOD-23858 | ArrayExpress
2010-08-14 | E-GEOD-23110 | ArrayExpress
2012-09-16 | E-GEOD-36650 | ArrayExpress
2011-07-03 | E-GEOD-27968 | ArrayExpress
2013-08-08 | E-GEOD-48610 | ArrayExpress