Transcriptomics,Multiomics

Dataset Information

3

Gain of the oncostatin M receptor in cervical squamous cell carcinoma is associated with adverse clinical outcome


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE27331: Gain of the oncostatin M receptor in cervical squamous cell carcinoma is associated with adverse clinical outcome [penn1Mb data] GSE27332: Gain of the oncostatin M receptor in cervical squamous cell carcinoma is associated with adverse clinical outcome [camb1Mb data] GSE27673: An integrated genomics approach for novel biomarker discovery in squamous cell cervical carcinoma Refer to individual Series

ORGANISM(S): Homo Sapiens

TISSUE(S): Cell Line, Cervix, Uterine Cervix

SUBMITTER: Ian Roberts  

PROVIDER: E-GEOD-27333 | ArrayExpress | 2011-02-16

SECONDARY ACCESSION(S): GSE27333PRJNA137311

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-27333.README.txt Txt
E-GEOD-27333.eSet.r Other
E-GEOD-27333.idf.txt Idf
E-GEOD-27333.processed.1.zip Processed
E-GEOD-27333.raw.1.zip Raw
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Publications

Gain and overexpression of the oncostatin M receptor occur frequently in cervical squamous cell carcinoma and are associated with adverse clinical outcome.

Ng G G   Winder D D   Muralidhar B B   Gooding E E   Roberts I I   Pett M M   Mukherjee G G   Huang J J   Coleman N N  

The Journal of pathology 20070701 3


For many oncogenes, increased expression resulting from copy number gain confers a selective advantage to cells that consequently make up the tumour bulk. To identify oncogenes of potential biological significance in cervical squamous cell carcinoma (SCC), 36 primary samples and ten cell lines were screened by array comparative genomic hybridization (CGH). The most commonly occurring regions of copy number gain that also showed amplification were 5p15.2-14.3 (59%), 5p13.3 (65%), and 5p13.2-13.1  ...[more]

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