Transcriptomics

Dataset Information

8

ENCODE: two phosphorylation states of RNAP II ChIP-chip from HeLa cells


ABSTRACT: Two phosphorylation states of RNAPII in HeLa cells Keywords: ChIP-chip Study of RNAPII binding patterns to ENCODE regions. 3 arrays using 8wg16 antibody, hypophosphoryated PolII, 3 arrays using 4H8 antibody, phosphorylated PolII CTD, and 6 input DNA arrays.

ORGANISM(S): Homo sapiens  

SUBMITTER: Xiaole Liu   Edward Fox  Clifford Meyer  Giles Hall  Alexander Brodsky  Ian Swinburne  Benjamin Keenan  Pamela Silver 

PROVIDER: E-GEOD-2735 | ArrayExpress | 2010-06-10

SECONDARY ACCESSION(S): GSE2735

REPOSITORIES: GEO, ArrayExpress

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Publications

Genomic mapping of RNA polymerase II reveals sites of co-transcriptional regulation in human cells.

Brodsky Alexander S AS   Meyer Clifford A CA   Swinburne Ian A IA   Hall Giles G   Keenan Benjamin J BJ   Liu Xiaole S XS   Fox Edward A EA   Silver Pamela A PA  

Genome biology 20050715 8


Transcription by RNA polymerase II is regulated at many steps including initiation, promoter release, elongation and termination. Accumulation of RNA polymerase II at particular locations across genes can be indicative of sites of regulation. RNA polymerase II is thought to accumulate at the promoter and at sites of co-transcriptional alternative splicing where the rate of RNA synthesis slows.To further understand transcriptional regulation at a global level, we determined the distribution of RN  ...[more]

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