Dataset Information


Expression data for HIF1alpha-regulated genes in clear cell renal carcinoma cells (ccRCC)

ABSTRACT: Gene expression profiling was performed in ccRCC cells, which either express both HIF1alpha and HIF2alpha (either naturally or by virtue of induced expression of HIF1alpha) or express HIF2alpha alone (either naturally or by virtue of a HIF1alpha shRNA), to identify genes regulated by HIF1alpha in ccRCC cells. Three H2 cell lines 769P, A498, and SLR24 were stably infected with retrovirus encoding doxycycline-inducible Luciferase (control) or HIF1alpha, and two H1H2 cell lines Caki-2 and SLR25 were stably infected with retroviruses encoding scrambled (control) or HIF1alpha shRNA. Duplicated samples were used for each condition.

ORGANISM(S): Homo sapiens  

SUBMITTER: Shen Chuan   Kaelin William  Chuan Shen 

PROVIDER: E-GEOD-27415 | ArrayExpress | 2011-12-02



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Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene.

Shen Chuan C   Beroukhim Rameen R   Schumacher Steven E SE   Zhou Jing J   Chang Michelle M   Signoretti Sabina S   Kaelin William G WG  

Cancer discovery 20110607 3

Kidney cancers often delete chromosome 3p, spanning the VHL tumor suppressor gene, and chromosome 14q, which presumably harbors ≥ 1 tumor suppressor genes. pVHL inhibits the hypoxia-inducible transcription factor (HIF), and HIF2α is a kidney cancer oncoprotein. In this article, we identify focal, homozygous deletions of the HIF1α locus on 14q in clear cell renal carcinoma cell lines. Wild-type HIF1α suppresses renal carcinoma growth, but the products of these altered loci do not. Conversely, dow  ...[more]

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