Transcriptomics

Dataset Information

4

The Cdk-activating kinase (CAK) couples cell growth to cell division


ABSTRACT: We report that inactivation of the fission yeast Cdk7 kinase affects gene expression through both its RNA Polymerase II CTD kinase activity and its Cdc2-activating kinase activity. The ribosome biogenesis cluster is specifically downregulated when Cdc2 T167 phosphorylation is abolished, which results is slow growth. We propose that Cdc2 activation by CAK defines the rate change point observed in mid G2 and that CAK therefore couples cell growth to cell division. Total RNA was isolated from two biological replicates for all conditions, and each biological replicate was hybridized in duplicate on Agilent arrays (dye-swap).

ORGANISM(S): Schizosaccharomyces pombe  

SUBMITTER: Maxime Devos   Jean Vandenhaute  Damien Hermand  Damien Coudreuse  Harm van Bakel  Monique Dewez 

PROVIDER: E-GEOD-27425 | ArrayExpress | 2012-02-19

SECONDARY ACCESSION(S): GSE27425PRJNA137229

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-27425.README.txt Txt
E-GEOD-27425.idf.txt Idf
E-GEOD-27425.processed.1.zip Processed
E-GEOD-27425.raw.1.zip Raw
E-GEOD-27425.raw.2.zip Raw
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