Transcriptomics

Dataset Information

8

Comparison of gene expression profiles of normal human bronchial epithelial cells in 2D and 3D cultural conditions


ABSTRACT: The experiment is part of a project to study DNA repair process after ionizing radiation in organotypic 3-dimentional human bronchial epithlial cell culture. Human bronchial epithelial cells were grown in tissue culture flask (2D) or in matrics gel (3D). Three independent cultures were done for each condition.

ORGANISM(S): Homo sapiens  

SUBMITTER: Lianghao Ding   John D Minna  Aroumougame Asaithamby  David J Chen  Oliver Delgado  Michael D Story  Jerry W Shay  Burong Hu 

PROVIDER: E-GEOD-27520 | ArrayExpress | 2011-07-26

SECONDARY ACCESSION(S): GSE27520PRJNA137103

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture.

Asaithamby Aroumougame A   Hu Burong B   Delgado Oliver O   Ding Liang-Hao LH   Story Michael D MD   Minna John D JD   Shay Jerry W JW   Chen David J DJ  

Nucleic acids research 20110318 13


DNA damage and consequent mutations initiate the multistep carcinogenic process. Differentiated cells have a reduced capacity to repair DNA lesions, but the biological impact of unrepaired DNA lesions in differentiated lung epithelial cells is unclear. Here, we used a novel organotypic human lung three-dimensional (3D) model to investigate the biological significance of unrepaired DNA lesions in differentiated lung epithelial cells. We showed, consistent with existing notions that the kinetics o  ...[more]

Similar Datasets

2011-07-27 | GSE27520 | GEO
| GSE71259 | GEO
| GSE115947 | GEO
2015-06-30 | E-GEOD-53550 | ArrayExpress
2011-06-01 | E-GEOD-26148 | ArrayExpress
2018-07-26 | GSE109733 | GEO
2014-03-31 | E-GEOD-49518 | ArrayExpress
2011-06-01 | GSE26148 | GEO
2010-07-30 | E-GEOD-17347 | ArrayExpress
2007-05-02 | E-TABM-244 | ArrayExpress