Dataset Information


Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients

ABSTRACT: Comment on published article "Massive genomic rearrangement acquired in a single catastrophic event during cancer development." by Stephens, P.J., Greenman, C.D., Beiyuan, F., Yang, F., Bignell, G.R., Mudie, L.J., Pleasance, E.D., Lau, K.W., Beare, D., Stebbings, L.A., et al. (2011). Cell 144, 27-40. [PMID: 21215367] 10 myeloma patients examined with high resolution genome-wide chip SUPPLEMENTARY FILE: Copy number table.

ORGANISM(S): Homo sapiens  

SUBMITTER: Hervé Avet-Loiseau   Florence Magrangeas  Stéphane Minvielle  Wilfried Gouraud 

PROVIDER: E-GEOD-27560 | ArrayExpress | 2011-06-06



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Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients.

Magrangeas Florence F   Avet-Loiseau Hervé H   Munshi Nikhil C NC   Minvielle Stéphane S  

Blood 20110531 3

Multiple myeloma (MM) develops from a premalignant plasma cell proliferative disorder, and with time can progress to a more aggressive disease in extramedullary locations. The gradually clinical evolution is supported by clonal expansion of cells that acquire genetic lesions over years. This model of cancer evolution based on ongoing genomic instability mechanism may apply to development of most MM cases. However, in a small fraction of newly diagnosed MM who relapse quickly and finally die with  ...[more]

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