Dataset Information


Differential expression of microRNA profiles from the peripheral blood of type 1 and type 2 diabetic patients

ABSTRACT: Using microarray, we compared the expression of miRNAs from the peripheral blood of male subjects with T1DM and T2DM with healthy controls. Healthy male controls used were age-matched to the T2DM group patients with mean(SD) 37.3 (7.1) years. Subjects with T1DM were younger [23.3(1.6) years]. Expression was compared and validated using quantitative real-time PCR. Statistical testing (ANOVA, P-value <0.05) was performed and fold changes with respect to the control were calculated Systolic BP, fasting glucose, HbA1c, total cholesterol and LDL-cholesterol levels were significantly higher in T2DM subjects compared with controls (P-value <0.05). Compared with controls, we identified 37 differentially regulated miRNAs in DM subjects. Among them, 21 miRNAs were upregulated (2-5 fold change, p-value < 0.05) and 16 miRNAs were downregulated (1.5-2 fold change, p-value < 0.05). These miRNAs had gene putative targets primarily involved in regulating pancreatic development and functions, adipocyte differentiation, insulin signaling and glucose-dependent insulin secretion. peripheral blood of male subjects with T1DM and T2DM with healthy controls

ORGANISM(S): Homo sapiens  

SUBMITTER: Chin M Khoo   Arunmozhiarasi Armugam  Dwi S Karolina  Kandiah Jeyaseelan 

PROVIDER: E-GEOD-27645 | ArrayExpress | 2011-03-05



Similar Datasets

2011-03-05 | GSE27645 | GEO
2014-07-30 | E-GEOD-50866 | ArrayExpress
| GSE97123 | GEO
| GSE90028 | GEO
2012-05-30 | E-MEXP-3286 | ArrayExpress
2014-06-15 | E-GEOD-54692 | ArrayExpress
2014-06-10 | E-GEOD-55515 | ArrayExpress
| GSE19420 | GEO
2010-11-29 | E-GEOD-19420 | ArrayExpress
2014-08-04 | E-GEOD-58868 | ArrayExpress