Transcriptomics

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Highly Pathogenic Avian Influenza Viruses Avoid Effective Inflammatory Response of Human Macrophages


ABSTRACT: Macrophages were infected with low (PR8) and high pathogenic influenza viruses (FPV and H5N1). To our surprise a genome-wide comparative systems biology approach revealed that in contrast PR8 infections with HPAIV H5N1 and FPV result in a reduced immune response of human macrophages contradicting a primary role of this cell type for the cytokine storm. Our data point to a viral strategy of HPAIV to bypass a major amplifier of the initial local inflammatory response thereby hampering antiviral effector mechanisms and facilitating virus spreading and systemic disease. Macrophages were infected with low (PR8) and high pathogenic influenza viruses (FPV and H5N1)

ORGANISM(S): Homo sapiens  

SUBMITTER: Dorothee Viemann  Eike Hrincius   Stephan Ludwig   Judith Friesenhagen   Yvonne Börgeling   Johannes Roth    

PROVIDER: E-GEOD-27702 | ArrayExpress | 2012-05-28

SECONDARY ACCESSION(S): GSE27702PRJNA138131

REPOSITORIES: GEO, ArrayExpress

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Publications

Highly pathogenic avian influenza viruses inhibit effective immune responses of human blood-derived macrophages.

Friesenhagen Judith J   Boergeling Yvonne Y   Hrincius Eike E   Ludwig Stephan S   Roth Johannes J   Viemann Dorothee D  

Journal of leukocyte biology 20120321 1


Systemic infections with HPAIVs, such as H5N1, are characterized by cytokine burst and sepsis. We investigated the role of human monocyte-derived macrophages in these events after infection with different influenza virus strains. Macrophages were infected with low pathogenic H1N1 (PR8) or high pathogenic H7N7 (FPV) and H5N1 (KAN-1) subtypes. Macrophages were found to be nonpermissive for influenza virus propagation. Surprisingly, transcriptome analysis revealed an insufficient innate immune resp  ...[more]

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