Transcriptomics

Dataset Information

7

Transcription profiling by array of immature ovariectomized mice after treatment with 17-alpha-ethynylestradiol


ABSTRACT: Immature, ovariectomized C57BL/6 mice were treated with sesame oil (vehicle) or with 0.1 mg/kg 17-alpha-ethynylestradiol (EE) for the length of time indicated. Mice received one dose, except for the 3x24hr samples, which received 3 consecutive daily doses and were sacrificed 24hr after the final dose. Two replicates of each sample are provided. In addition, one time=0 sample is included.

ORGANISM(S): Mus musculus  

SUBMITTER: Tim Zacharewski  

PROVIDER: E-GEOD-280 | ArrayExpress | 2007-12-13

SECONDARY ACCESSION(S): GDS285GSE280PRJNA84717

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-280.README.txt Txt
E-GEOD-280.idf.txt Idf
E-GEOD-280.processed.1.zip Processed
E-GEOD-280.sdrf.txt Txt
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Publications

Identification of temporal patterns of gene expression in the uteri of immature, ovariectomized mice following exposure to ethynylestradiol.

Fertuck K C KC   Eckel J E JE   Gennings C C   Zacharewski T R TR  

Physiological genomics 20031017 2


Estrogen induction of uterine wet weight provides an excellent model to investigate relationships between changes in global gene expression and well-characterized physiological responses. In this study, time course microarray GeneChip data were analyzed using a novel approach to identify temporal changes in uterine gene expression following treatment of immature ovariectomized C57BL/6 mice with 0.1 mg/kg 17alpha-ethynylestradiol. Functional gene annotation information from public databases facil  ...[more]

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