Transcriptomics

Dataset Information

4

Human oocytes reprogram somatic cells to a pluripotent state


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE27507: Gene expression in pluripotent stem cells derived after somatic cell genome transfer into human oocytes GSE28022: Gene expression in blastomeres after transfer of somatic cells into human oocytes Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Dieter Egli  

PROVIDER: E-GEOD-28024 | ArrayExpress | 2011-10-05

SECONDARY ACCESSION(S): GSE28024PRJNA137969

REPOSITORIES: GEO, ArrayExpress

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Publications


The exchange of the oocyte's genome with the genome of a somatic cell, followed by the derivation of pluripotent stem cells, could enable the generation of specific cells affected in degenerative human diseases. Such cells, carrying the patient's genome, might be useful for cell replacement. Here we report that the development of human oocytes after genome exchange arrests at late cleavage stages in association with transcriptional abnormalities. In contrast, if the oocyte genome is not removed  ...[more]

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