Dataset Information


Transcription profiling of human monocytes infected with adenovirus expressing either c-Myb or v-Myb

ABSTRACT: The transcriptional activities of c-Myb and its oncogenic variant v-Myb were compared by expressing them in primary human monocytes using recombinant adenovirus vectors. All the samples were compared to cells infected with a control adenovirus expressing only GFP. The results showed that v-Myb, which differs from c-Myb only by N- and C-terminal deletions and eleven amino acid substitutions, has a qualitatively different transcriptional activity. Experiment Overall Design: 2 replicates of each type were analyzed. Replicates were performed independently, more than a week apart.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Scott A. Ness  

PROVIDER: E-GEOD-2816 | ArrayExpress | 2007-12-12



altmetric image


Oncogenic mutations cause dramatic, qualitative changes in the transcriptional activity of c-Myb.

Liu F F   Lei W W   O'Rourke J P JP   Ness S A SA  

Oncogene 20060201 5

The v-Myb oncoprotein encoded by Avian Myeloblastosis Virus is highly oncogenic, induces leukemias in chickens and mice and transforms immature hematopoietic cells in vitro. The v-Myb protein is a mutated and truncated version of c-Myb, a DNA-binding transcription factor expressed in many cell types that is essential for normal hematopoiesis. Previous studies suggested that two types of differences, DNA binding domain mutations and the deletion of a C-terminal negative regulatory domain were imp  ...[more]

Similar Datasets

2007-12-12 | E-GEOD-2815 | ArrayExpress
2008-06-11 | E-GEOD-1318 | ArrayExpress
2017-10-04 | PXD006857 | Pride
| GSE74140 | GEO
2015-10-22 | E-MEXP-2449 | ExpressionAtlas
| PRJNA341411 | ENA
2009-12-31 | E-MEXP-2449 | ArrayExpress
2011-08-04 | E-GEOD-30745 | ArrayExpress
| PRJEB3253 | ENA
| PRJNA399039 | ENA