Dataset Information


Transcription profiling time series of human epidermal keratinocytes treated with Oncostatin-M

ABSTRACT: Cultured epidermal keratinocytes treated with OsM 1, 4, 24 & 48hrs, and Skinethic epidermal substitutes treated 1, 4, 24, 48h & 7days, each with untreated control Experiment Overall Design: Each timepoint has treated/untreated matched control. Experiment Overall Design: Skinethic 4h treated was replicated. Experiment Overall Design: Note: OncostatinM treatment, GSM61488, is the 1h control!!

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Homo sapiens  

SUBMITTER: Miki Blumenberg  

PROVIDER: E-GEOD-2822 | ArrayExpress | 2007-12-12



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Transcriptional responses of human epidermal keratinocytes to Oncostatin-M.

Finelt Nika N   Gazel Alix A   Gorelick Steven S   Blumenberg Miroslav M  

Cytokine 20050801 4

Oncostatin-M (OsM) plays an important role in inflammatory and oncogenic processes in skin, including psoriasis and Kaposi sarcoma. However, the molecular responses to OsM in keratinocytes have not been explored in depth. Here we show the results of transcriptional profiling in OsM-treated primary human epidermal keratinocytes, using high-density DNA microarrays. We find that OsM strongly and specifically affects the expression of many genes, in particular those involved with innate immunity, an  ...[more]

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