Genomics

Dataset Information

244

Changes in H3K4 methylation in KDM5A/JARID1A/RBP2 knockout cells.


ABSTRACT: We sought to determine H3K4me3 distribution in mouse embryonic stem (ES) cells deficient for RBP2 compared with wild-type cells. RBP2 modifies methylated lysine residues on histone tails. As a result of this analysis, we identified genomic regions with changed H3K4me3 status and described these in gene ontology (GO) categories. Examination of histone methylation in the absence of histone demethylase RBP2

ORGANISM(S): Mus musculus  

SUBMITTER: Elizaveta Benevolenskaya   Elizaveta V Benevolenskaya  Abul Islam 

PROVIDER: E-GEOD-28348 | ArrayExpress | 2015-08-12

SECONDARY ACCESSION(S): SRP006296GSE28348PRJNA139457

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Genome-wide analysis using ChIP to identify isoform-specific gene targets.

Beshiri Michael L ML   Islam Abul A   DeWaal Dannielle C DC   Richter William F WF   Love Jennifer J   Lopez-Bigas Nuria N   Benevolenskaya Elizaveta V EV  

Journal of visualized experiments : JoVE 20100707 41


Recruitment of transcriptional and epigenetic factors to their targets is a key step in their regulation. Prominently featured in recruitment are the protein domains that bind to specific histone modifications. One such domain is the plant homeodomain (PHD), found in several chromatin-binding proteins. The epigenetic factor RBP2 has multiple PHD domains, however, they have different functions (Figure 4). In particular, the C-terminal PHD domain, found in a RBP2 oncogenic fusion in human leukemia  ...[more]

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