Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA137519PRJNA141973PRJNA141951PRJNA139441
ORGANISM(S): Mus musculus
SUBMITTER: Anja Ebert Shane McManus Meinrad Busslinger
PROVIDER: E-GEOD-28373 | ArrayExpress | 2012-03-29
SECONDARY ACCESSION(S): GSE28373PRJNA139441
REPOSITORIES: GEO, ArrayExpress
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E-GEOD-28373.README.txt | Txt | |||
E-GEOD-28373.idf.txt | Idf | |||
E-GEOD-28373.processed.1.zip | Processed | |||
E-GEOD-28373.raw.1.zip | Raw | |||
E-GEOD-28373.raw.2.zip | Raw |
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The EMBO journal 20110506 12
Pax5 is a critical regulator of B-cell commitment. Here, we identified direct Pax5 target genes by streptavidin-mediated ChIP-chip analysis of pro-B cells expressing in vivo biotinylated Pax5. By binding to promoters and enhancers, Pax5 directly regulates the expression of multiple transcription factor, cell surface receptor and signal transducer genes. One of the newly identified enhancers was shown by transgenic analysis to confer Pax5-dependent B-cell-specific activity to the Nedd9 gene contr ...[more]