Transcriptomics

Dataset Information

3

EZH2 over-expression is associated with gain of chromosome arm 7q and essential for cell cycle progression and a marker of poor prognosis in neuroblastoma


ABSTRACT: Neuroblastoma is an often aggressive childhood cancer with several large chromosomal regions showing recurrent gains or losses. Chromosome 7q is gained in 40-60% of neuroblastomas, but despite being the second most frequent genomic aberration, no oncogenes have been linked to 7q gain. We performed expression profiling and array CGH on 88 primary neuroblastoma tumors to identify a 7q oncogene. We assayed neuroblastoma cell lines and combined bioinformatic analyses on the in vitro and in vivo data.

ORGANISM(S): Homo sapiens  

SUBMITTER: Peter van Sluis   Jan Koster  Mireille H Indemans  Rogier Versteeg  Dirk Geerts  Katleen de Preter  Ingrid Øra  Jan J Molenaar  Frank Speleman  Hinco J Gierman  Chrisoula Efstathiadou  Marli E Ebus  Richard Volckmann 

PROVIDER: E-GEOD-28409 | ArrayExpress | 2013-10-06

SECONDARY ACCESSION(S): GSE28409PRJNA139169

REPOSITORIES: GEO, ArrayExpress

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