Dataset Information


Comparison between syngeneic kidney transplant and a model of allogeneic kidney transplant tolerance induced by anti-classII regimen in the rat

ABSTRACT: The goal is to identify new molecules implicated in tolerance, to determine the implication of these molecules in immune responses to transplantation by gene expression comparison of 27,088 individual rat genes between tolerated kidney allotransplant and syngeneic kidney transplant. In this study 27,088 individual rat genes expression from total mRNA of 3 tolerated allogeneic kidney transplants by anti-classII, were compared to 3 syngeneic kidney transplants at day 100 post transplantation.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: Romain Vuillefroy de Silly   Vojislav Jovanovic  Sophie Brouard  Richard Danger 

PROVIDER: E-GEOD-28474 | ArrayExpress | 2011-04-09



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Transplant tolerance is associated with reduced expression of cystathionine-γ-lyase that controls IL-12 production by dendritic cells and TH-1 immune responses.

Vuillefroy de Silly Romain R   Coulon Flora F   Poirier Nicolas N   Jovanovic Vojislav V   Brouard Sophie S   Ferchaud-Roucher Véronique V   Blancho Gilles G   Vanhove Bernard B  

Blood 20120119 11

Antigen-activated T lymphocytes undergo an immune or tolerogeneic response in part according to the activation status of their antigen-presenting cells. However, factors controlling the activation of antigen-presenting cells are not fully understood. In this study, we demonstrate that immune tolerance after organ allotransplantation in the rat is associated with a repressed intragraft expression of several enzymes of the trans-sulfuration pathway, including cystathionine γ-lyase (CSE). The pharm  ...[more]

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