Genomics

Dataset Information

4

Transcription profiling time series of Rattus norvegicus liver and kidney samples from animals treated with ochratoxin A and controls


ABSTRACT: Ochratoxin A gene expression profiling in liver and kidney, with time points of exposure from 7 days to 12 months Experiment Overall Design: three replicates for each timepoint measured, control and ochratoxin A treated for both liver and kidney.

Note that files GSM62732.CEL and GSM62733.CEL, and files GSM62730.CEL and GSM62739.CEL as downloaded from GEO contain identical data.

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Rattus norvegicus  

TISSUE(S): Liver, Kidney

SUBMITTER: James Holzwarth  

PROVIDER: E-GEOD-2852 | ArrayExpress | 2007-10-10

SECONDARY ACCESSION(S): GSE2852PRJNA92563

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-2852.README.txt Txt
E-GEOD-2852.eSet.r Other
E-GEOD-2852.idf.txt Idf
E-GEOD-2852.processed.1.zip Processed
E-GEOD-2852.raw.1.zip Raw
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Publications

A toxicogenomics approach to identify new plausible epigenetic mechanisms of ochratoxin a carcinogenicity in rat.

Marin-Kuan M M   Nestler S S   Verguet C C   Bezençon C C   Piguet D D   Mansourian R R   Holzwarth J J   Grigorov M M   Delatour T T   Mantle P P   Cavin C C   Schilter B B  

Toxicological sciences : an official journal of the Society of Toxicology 20051026 1


Ochratoxin A (OTA) is a mycotoxin occurring naturally in a wide range of food commodities. In animals, it has been shown to cause a variety of adverse effects, nephrocarcinogenicity being the most prominent. Because of its high toxic potency and the continuous exposure of the human population, OTA has raised public health concerns. There is significant debate on how to use the rat carcinogenicity data to assess the potential risk to humans. In this context, the question of the mechanism of actio  ...[more]

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