Transcriptomics

Dataset Information

2

Effects of 20 months Dietary Methionine Restriction on Gene Expression in inguinal white adipose tissue of Fischer 344 Rats


ABSTRACT: Dietary methionine restriction (MR) has been shown to increase lifespan and decrease adiposity in rodents. This study was designed to examine the transcriptional effects of MR in metabolically relevant tissues. This experiment contains data from the inguinal white adipose tissue (IWAT). We analyzed MR-induced changes in gene expression using pooled RNA from IWAT of rats fed either a control purified amino acid diet (DL-methionine content of 0.86%) (CON) or a methionine-restricted diet (DL-methionine content of 0.172%)(MR). Rats were fed Purina rodent diet 5001 until 32 days of age and were then randomly assigned to be fed CON diet or MR diet for 20 months.

ORGANISM(S): Rattus norvegicus  

SUBMITTER: A Boudreau   B E Hasek  Kirsten P Stone  L K Stewart  N R Lenard  E P Plaisance  T M Henagan  T W Gettys 

PROVIDER: E-GEOD-28599 | ArrayExpress | 2013-07-01

SECONDARY ACCESSION(S): GSE28599PRJNA139099

REPOSITORIES: GEO, ArrayExpress

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Publications

Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats.

Hasek Barbara E BE   Boudreau Anik A   Shin Jeho J   Feng Daorong D   Hulver Matthew M   Van Nancy T NT   Laque Amanda A   Stewart Laura K LK   Stone Kirsten P KP   Wanders Desiree D   Ghosh Sujoy S   Pessin Jeffrey E JE   Gettys Thomas W TW  

Diabetes 20130625 10


Dietary methionine restriction (MR) produces an integrated series of biochemical and physiological responses that improve biomarkers of metabolic health, limit fat accretion, and enhance insulin sensitivity. Using transcriptional profiling to guide tissue-specific evaluations of molecular responses to MR, we report that liver and adipose tissue are the primary targets of a transcriptional program that remodeled lipid metabolism in each tissue. The MR diet produced a coordinated downregulation of  ...[more]

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