Dataset Information


Genome wide H3K9ac and SAGA occupancy at OX growth phase and RC quiescent phase of yeast metabolic cycle

ABSTRACT: We found acetyl-CoA levels increase when cells are committed to growth. We also found 3 components of the SAGA complex, Spt7p, Sgf73p and Ada3p as well as histones are dynamically acetylated in tune with the acetyl-CoA levels. ChIP-seq study reveals SAGA and H3K9ac predominantly occupy growth genes at the OX growth phase of the yeast metabolic cycle indicating acetyl-CoA levels may drive growth gene transcription program through acetylation of these proteins. Examination of H3K9ac and SAGA binding over two timepoints using H3 and Input as controls

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Benjamin P Tu   Ling Cai 

PROVIDER: E-GEOD-28734 | ArrayExpress | 2011-05-19



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Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes.

Cai Ling L   Sutter Benjamin M BM   Li Bing B   Tu Benjamin P BP  

Molecular cell 20110501 4

The decision by a cell to enter a round of growth and division must be intimately coordinated with nutrient availability and its metabolic state. These metabolic and nutritional requirements, and the mechanisms by which they induce cell growth and proliferation, remain poorly understood. Herein, we report that acetyl-CoA is the downstream metabolite of carbon sources that represents a critical metabolic signal for growth and proliferation. Upon entry into growth, intracellular acetyl-CoA levels  ...[more]

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