Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA130441PRJNA143371PRJNA130905PRJNA136037PRJNA140285
ORGANISM(S): Homo Sapiens
SUBMITTER: Guoliang Li Edison T Liu Say L Kong
PROVIDER: E-GEOD-29073 | ArrayExpress | 2011-09-05
SECONDARY ACCESSION(S): SRP006701GSE29073PRJNA140285
REPOSITORIES: GEO, ArrayExpress, ENA
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E-GEOD-29073.idf.txt | Idf | |||
E-GEOD-29073.processed.1.zip | Processed | |||
E-GEOD-29073.processed.2.zip | Processed | |||
E-GEOD-29073.processed.3.zip | Processed | |||
E-GEOD-29073.sdrf.txt | Txt |
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Molecular systems biology 20110830
Despite the role of the estrogen receptor α (ERα) pathway as a key growth driver for breast cells, the phenotypic consequence of exogenous introduction of ERα into ERα-negative cells paradoxically has been growth inhibition. We mapped the binding profiles of ERα and its interacting transcription factors (TFs), FOXA1 and GATA3 in MCF-7 breast carcinoma cells, and observed that these three TFs form a functional enhanceosome that regulates the genes driving core ERα function and cooperatively modul ...[more]