Dataset Information


Gene profile of mid-log phase of SD medium grown Candida albicans rhb1 gene deletion strain

ABSTRACT: Candida albicans is an opportunistic pathogenic yeast that is commensally found in variety of host niches. Rhb1 serves as an positive regulator of Tor1 kinase which is the central component of the TOR signaling in controlling several virulence factors. Here, we used microarray to determined changes in transcript profile while the cell lacks the RHB1 gene. 10 array generated by six batchs of individual experiment (from cell isolation to culture); each included one flask of wild type culture (SC5314) and one flask of rhb1∆ (CCT-D1)mutant culture.

ORGANISM(S): Candida albicans  

SUBMITTER: Chung Y Lan   Wen P Hsieh  Pei W Tsai  Yu-Ting Chen  Yu T Chen 

PROVIDER: E-GEOD-29128 | ArrayExpress | 2012-03-15



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Rhb1 regulates the expression of secreted aspartic protease 2 through the TOR signaling pathway in Candida albicans.

Chen Yu-Ting YT   Lin Chia-Ying CY   Tsai Pei-Wen PW   Yang Cheng-Yao CY   Hsieh Wen-Ping WP   Lan Chung-Yu CY  

Eukaryotic cell 20111222 2

Candida albicans is a major fungal pathogen in humans. In C. albicans, secreted aspartyl protease 2 (Sap2) is the most highly expressed secreted aspartic protease in vitro and is a virulence factor. Recent research links the small GTPase Rhb1 to C. albicans target of rapamycin (TOR) signaling in response to nitrogen availability. The results of this study show that Rhb1 is related to cell growth through the control of SAP2 expression when protein is the major nitrogen source. This process involv  ...[more]

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