Genomics,Multiomics

Dataset Information

3

Identification of the tumor suppressor gene at chromosome 5q21


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE29227: aCGH profiling of prostate tumors GSE29228: 5q21 tiling array on prostate tumors GSE33531: Gene expression profiling of prostate cells with CHD1 knockdown Refer to individual Series

OTHER RELATED OMICS DATASETS IN: PRJNA142939PRJNA142937PRJNA148905PRJNA139935

ORGANISM(S): Homo sapiens  

SUBMITTER: Stephanie Huang  

PROVIDER: E-GEOD-29229 | ArrayExpress | 2011-12-19

SECONDARY ACCESSION(S): GSE29229PRJNA139935

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-29229.README.txt Txt
E-GEOD-29229.eSet.r Other
E-GEOD-29229.idf.txt Idf
E-GEOD-29229.processed.1.zip Processed
E-GEOD-29229.raw.1.zip Raw
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Publications

Recurrent deletion of CHD1 in prostate cancer with relevance to cell invasiveness.

Huang S S   Gulzar Z G ZG   Salari K K   Lapointe J J   Brooks J D JD   Pollack J R JR  

Oncogene 20111219 37


Though prostate cancer is often indolent, it is nonetheless a leading cause of cancer death. Defining the underlying molecular genetic alterations may lead to new strategies for prevention or treatment. Towards this goal, we performed array-based comparative genomic hybridization (CGH) on 86 primary prostate tumors. Among the most frequent alterations not associated with a known cancer gene, we identified focal deletions within 5q21 in 15 out of 86 (17%) cases. By high-resolution tiling array CG  ...[more]

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