Transcriptomics

Dataset Information

3

Effect of endoglin loss on embryoid bodies


ABSTRACT: Analysis of embryonic sten cell-derived embryoid bodies following endoglin knock out. Loss of endoglin leads to profound reduction of key hematopoietic regulators including SCL, LMO2, Gata2, and TGF-β signaling molecule ALK-1. Results provide insight into molecular mechanisms underlying hemangioblast and primitive hematopoietic development. Total RNA obtained from differentiated day 3 EBs of endoglin knock out ES cells were compared to wild type E14 control ES cells.

ORGANISM(S): Mus musculus  

SUBMITTER: Rita Perlingeiro   Liying Zhang 

PROVIDER: E-GEOD-29300 | ArrayExpress | 2011-05-16

SECONDARY ACCESSION(S): GSE29300PRJNA138629

REPOSITORIES: GEO, ArrayExpress

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Publications

Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis.

Zhang Liying L   Magli Alessandro A   Catanese Jacquelyn J   Xu Zhaohui Z   Kyba Michael M   Perlingeiro Rita C R RC  

Blood 20110520 1


Endoglin (Eng), an accessory receptor for the transforming growth factor β (TGF-β) superfamily, is required for proper hemangioblast and primitive hematopoietic development. However the mechanism by which endoglin functions at this early developmental stage is currently unknown. Transcriptional analyses of differentiating eng(-/-) and eng(+/+) ES cells revealed that lack of endoglin leads to profound reductions in the levels of key hematopoietic regulators, including Scl, Lmo2, and Gata2. We als  ...[more]

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