Dataset Information


Effect of endoglin loss on embryoid bodies

ABSTRACT: Analysis of embryonic sten cell-derived embryoid bodies following endoglin knock out. Loss of endoglin leads to profound reduction of key hematopoietic regulators including SCL, LMO2, Gata2, and TGF-β signaling molecule ALK-1. Results provide insight into molecular mechanisms underlying hemangioblast and primitive hematopoietic development. Total RNA obtained from differentiated day 3 EBs of endoglin knock out ES cells were compared to wild type E14 control ES cells.

ORGANISM(S): Mus musculus  

SUBMITTER: Rita Perlingeiro   Liying Zhang 

PROVIDER: E-GEOD-29300 | ArrayExpress | 2011-05-16



altmetric image


Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis.

Zhang Liying L   Magli Alessandro A   Catanese Jacquelyn J   Xu Zhaohui Z   Kyba Michael M   Perlingeiro Rita C R RC  

Blood 20110520 1

Endoglin (Eng), an accessory receptor for the transforming growth factor β (TGF-β) superfamily, is required for proper hemangioblast and primitive hematopoietic development. However the mechanism by which endoglin functions at this early developmental stage is currently unknown. Transcriptional analyses of differentiating eng(-/-) and eng(+/+) ES cells revealed that lack of endoglin leads to profound reductions in the levels of key hematopoietic regulators, including Scl, Lmo2, and Gata2. We als  ...[more]

Similar Datasets

2011-05-16 | GSE29300 | GEO
| GSE77390 | GEO
2012-04-22 | E-GEOD-37515 | ArrayExpress
| GSE6835 | GEO
2007-01-25 | E-GEOD-6835 | ArrayExpress
2008-04-01 | GSE10148 | GEO
| GSE86197 | GEO
2014-02-03 | E-GEOD-45147 | ArrayExpress
| GSE56359 | GEO
| GSE86196 | GEO