Transcriptomics

Dataset Information

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Gene expression profiling of MCF10A (miR-221/222 vs control)


ABSTRACT: Analysis of gene expression of MCF10A to identify the targets of miR-221 and miR-222 Keywords: MCF10, miR-221, miR-222 RNA profiles of human MCF10A cell line

REANALYSED by: E-GEOD-29327

OTHER RELATED OMICS DATASETS IN: E-GEOD-12764

ORGANISM(S): Homo sapiens  

SUBMITTER: Peng Yue  David Dornan    

PROVIDER: E-GEOD-29327 | ArrayExpress | 2011-06-14

SECONDARY ACCESSION(S): GSE29327PRJNA140123

REPOSITORIES: GEO, ArrayExpress

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Publications


The basal-like subtype of breast cancer has an aggressive clinical behavior compared to that of the luminal subtype. We identified the microRNAs (miRNAs) miR-221 and miR-222 (miR-221/222) as basal-like subtype-specific miRNAs and showed that expression of miR-221/222 decreased expression of epithelial-specific genes and increased expression of mesenchymal-specific genes, and increased cell migration and invasion in a manner characteristic of the epithelial-to-mesenchymal transition (EMT). The tr  ...[more]

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