Dataset Information


Transcriptome analysis of OECM1 after expression of let-7i

ABSTRACT: Expression of let-7i results in transcriptome alteractions in head and neck cancer cell line, OECM1. Stable transfection of pmCherry-let7i in OECM1 cell and analyzed the transcriptome by cDNA microarray. OECM1 transfected with pmCherry empty vector was used as a control of experiment.

ORGANISM(S): Homo sapiens  

SUBMITTER: Muh-Hwa Yang   Wen-Hao Yang 

PROVIDER: E-GEOD-29539 | ArrayExpress | 2013-02-11



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RAC1 activation mediates Twist1-induced cancer cell migration.

Yang Wen-Hao WH   Lan Hsin-Yi HY   Huang Chi-Hung CH   Tai Shyh-Kuan SK   Tzeng Cheng-Hwai CH   Kao Shou-Yen SY   Wu Kou-Juey KJ   Hung Mien-Chie MC   Yang Muh-Hwa MH  

Nature cell biology 20120311 4

Epithelial-mesenchymal transition (EMT), which is characterized by the suppression of the adhesion protein E-cadherin, is a crucial process that promotes metastasis and stem-like properties of cancer cells. However, the dissociation of cellular aggregates is not sufficient to explain why cancer cells move, and the motile nature of cancer cells undergoing EMT remains elusive. Here, we identify a mechanism in which the EMT inducer Twist1 elicits cancer cell movement through activation of RAC1. Twi  ...[more]

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