Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jeanette N McClintick Tracy G Anthony Brian F Teske Ron Wek Ronald C Wek Sheree A Wek
PROVIDER: E-GEOD-29929 | ArrayExpress | 2012-01-20
SECONDARY ACCESSION(S): GSE29929PRJNA140871
REPOSITORIES: GEO, ArrayExpress
Teske Brian F BF Wek Sheree A SA Bunpo Piyawan P Cundiff Judy K JK McClintick Jeanette N JN Anthony Tracy G TG Wek Ronald C RC
Molecular biology of the cell 20110914 22
Disruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER stress and elicit an unfolded protein response (UPR) that involves translational and transcriptional changes in gene expression aimed at expanding the ER processing capacity and alleviating cellular injury. Three ER stress sensors (PERK, ATF6, and IRE1) implement the UPR. PERK phosphorylation of the α subunit of eIF2 during ER stress represses protein synthesis, which prevents further influx of ER client proteins ...[more]